Nucleofill vs Rejuran vs Profhilo in Bali: Which Skin Booster Should You Get?
Updated July 2026
Published 22 July 2026 by Enzo
Nucleofill, Rejuran, and Profhilo are the three skin boosters visitors ask about most in Bali, and they are constantly confused for one another. They are not interchangeable. Two of them repair skin from the inside (Nucleofill and Rejuran), and one hydrates and firms (Profhilo). Picking the wrong one for your goal is the most common and most expensive skin-booster mistake.
This is a straight comparison built on verified Bali clinic prices, so you can walk into a consultation knowing which one you actually want.
The Core Difference in One Paragraph
Nucleofill and Rejuran are polynucleotides. They are made from purified DNA fragments (salmon-derived) that trigger the skin to repair itself, improving elasticity, texture, and thickness over a course of sessions. Profhilo is a hyaluronic acid bio-remodeller. It is a high-concentration HA that spreads under the skin to hydrate deeply and stimulate a subtle firming, giving that "glass skin" glow. Repair versus hydration is the whole decision.
Nucleofill vs Rejuran vs Profhilo at a Glance
Here is the side-by-side, built from verified Bali clinic pricing across our directory:
| Booster | What It Is | Best For | Bali Price (from) | Clinics | Starter Course |
|---|---|---|---|---|---|
| Nucleofill | Polynucleotide (repair) | Overall skin quality, elasticity, laxity | IDR 2,990,000 | Around 23 | 3 to 4 sessions |
| Rejuran | Polynucleotide (repair) | Acne scars, under-eye, thin skin | IDR 2,990,000 | 28 | 3 to 4 sessions |
| Profhilo | HA bio-remodeller (hydration) | Dull, dehydrated skin wanting glow | IDR 4,600,000 | 36 | 2 sessions |
The lowest entry points for Nucleofill, Rejuran (HB Plus), and Profhilo are all at Keina Beauty in Denpasar. Read on for where each one earns its place.
Nucleofill: The Polynucleotide Newer to the Bali Spotlight
Nucleofill is a polynucleotide treatment with surprisingly deep clinic coverage in Bali (around 23 clinics), even though few visitors search for it by name yet. It is strong for skin quality, laxity, and thin or tired-looking skin.
- Best for: overall skin quality, elasticity, and firmness, including the lower face and neck.
- Bali price: IDR 2,990,000 at Keina Beauty (the lowest), IDR 4,000,000 to 5,500,000 at most clinics including Radiance, Body Lab and Mysa, up to IDR 6,000,000 at CleanSlate and Lumina.
Rejuran: The Repair Specialist
Rejuran is the other polynucleotide, and the most brand-recognized booster in Bali (28 clinics). It comes in variants for the face, under-eyes (Rejuran I), and scars (Rejuran S), which makes it the most versatile of the three for targeted concerns.
- Best for: repair-led concerns, acne scarring, under-eye texture, and post-inflammation skin.
- Bali price: Rejuran Healer mostly IDR 4,000,000 to 6,500,000; Rejuran I from IDR 3,000,000; HB Plus from IDR 2,990,000 at Keina. Full breakdown in our Rejuran guide.
Profhilo: The Hydration and Glow Option
Profhilo has the deepest clinic coverage of all three (36 clinics) and is the one to choose when your skin looks dehydrated and flat rather than scarred or lax. It delivers a fast, visible glow.
- Best for: dehydrated, dull skin wanting a hydrated, subtly firmer glow with minimal injection points.
- Bali price: from IDR 4,600,000 at Keina, mostly IDR 6,500,000 to 8,000,000, up to IDR 10,000,000 for body treatments. Full breakdown in our Profhilo guide.
Decision Framework: Pick by Goal
- "My skin looks dull and dehydrated": Profhilo. Fastest visible glow.
- "I have acne scars or under-eye texture": Rejuran (S for scars, I for under-eyes). The repair specialist with targeted variants.
- "My skin feels thin, lax, or tired overall": Nucleofill or Rejuran Healer. Both polynucleotides build skin quality from within.
- "I want the best value entry point": Nucleofill or Rejuran HB at Keina Beauty, both from around IDR 2,990,000.
- "I want maximum firming without changing my face shape": a polynucleotide course, optionally layered with Profhilo for hydration.
All Three Are Course Treatments
One shared reality: none of these is a single-session fix. Polynucleotides (Nucleofill, Rejuran) typically need 3 to 4 sessions spaced 2 to 4 weeks apart. Profhilo is usually 2 sessions one month apart to start. For a visitor, that means one Bali trip rarely completes a full protocol, plan to start a course and continue it, or time two sessions around two trips.
Where to Compare All Three
Several clinics offer all three under one roof, which makes an in-person consultation the easiest way to decide: Body Lab (Seminyak, 4.9 stars, 996 reviews), Mysa Clinic (Canggu, 4.8 stars), Keina Beauty (Denpasar, 4.9 stars, the value pick), and Lumina (Legian, 4.9 stars, 1,000 reviews) all list Nucleofill, Rejuran, and Profhilo.
Browse the full skin boosters category or compare all 52+ clinics to build your plan.